刘剑锋

姓       名： 刘剑锋

职       称： 教授

所  在  系： 动物遗传育种系

研究方向： 数量遗传学、生物信息学理论和计算技术研究；基于多组学信息进行畜禽复杂性状遗传机理解析；以猪为对象进行常规育种和组学相结合的研究

电子邮箱： liujf@cau.edu.cn

《畜牧生物统计与试验设计》、《猪生产学》

《畜禽基因组学》、《动物育种原理和方法》

近五年主持国家自然基金项目3项、北京市自然基金项目1项、北京市科学技术委员会项目1项、农业财政项目3项。

主要发表论文：

1.  Fang M., Liu J., Sun D., Zhang Y., Zhang Q. & Zhang S. (2011) QTL mapping in outbred half-sib families using Bayesian model selection. Heredity 107, 265-76.

2.  Fu W.X., Liu Y., Lu X., Niu X.Y., Ding X.D., Liu J.F. & Zhang Q. (2012) A genome-wide association study identifies two novel promising candidate genes affecting Escherichia coli F4ab/F4ac susceptibility in swine. PLoS One 7, e32127.

3.  Fu W.X., Wang C.L., Ding X.D., Zhang Z., Ma P.P., Weng Z.Q., Liu J.F. & Zhang Q. (2012) Genome-wide association analyses of the 15th QTL-MAS workshop data using mixed model based single locus regression analysis. BMC Proc 6 Suppl 2, S5.

4.  Jiang J.C., Jiang L., Zhou B., Fu W.X., Liu J.F. & Zhang Q. (2011) Snat: a SNP annotation tool for bovine by integrating various sources of genomic information. Bmc Genetics 12.

5.  Jiang J., Wang J., Wang H., Zhang Y., Kang H., Feng X., Yin Z., Bao W., Zhang Q. & Liu J.F. (2014) Global copy number analyses by next generation sequencing provide insight into pig genome variation. BMC Genomics 15, 593.

6.  Jiang J., Zhang Q., Ma L., Li J., Wang Z. & Liu J.F. (2015) Joint prediction of multiple quantitative traits using a Bayesian multivariate antedependence model. Heredity 115, 29-36.

7.  Jiang L., Jiang J., Yang J., Liu X., Wang J., Wang H., Ding X., Liu J. & Zhang Q. (2013) Genome-wide detection of copy number variations using high-density SNP genotyping platforms in Holsteins. BMC Genomics 14, 131.

8.  Jiang L., Liu J., Sun D., Ma P., Ding X., Yu Y. & Zhang Q. (2010) Genome wide association studies for milk production traits in Chinese Holstein population. PLoS One 5, e13661.

9.  Liu J., Liu Y., Liu X. & Deng H.W. (2007) Bayesian mapping of quantitative trait loci for multiple complex traits with the use of variance components. American Journal of Human Genetics 81, 304-20.

10.  Liu J., Papasian C. & Deng H.W. (2007) Incorporating single-locus tests into haplotype cladistic analysis in case-control studies. Plos Genetics 3, e46.

11.  Liu J., Pei Y., Papasian C.J. & Deng H.W. (2009) Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations. Genetic Epidemiology 33, 217-27.

12.  Liu J., Zhang Y., Zhang Q., Wang L. & Zhang J. (2006) Study on mapping quantitative trait loci for animal complex binary traits using Bayesian-Markov chain Monte Carlo approach. Sci China C Life Sci 49, 552-9.

13.  Lu X., Fu W.X., Luo Y.R., Ding X.D., Zhou J.P., Liu Y., Liu J.F. & Zhang Q. (2012) Genome-wide association study for T lymphocyte subpopulations in swine. BMC Genomics 13, 488.

14.  Lu X., Liu J., Fu W., Zhou J., Luo Y., Ding X., Liu Y. & Zhang Q. (2013) Genome-wide association study for cytokines and immunoglobulin G in swine. PLoS One 8, e74846.

15.  Lu X., Liu J.F., Gong Y.F., Wang Z.P., Liu Y. & Zhang Q. (2011) Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine. Bmc Genetics 12, 79.

16.  Ma Y., Wei J., Zhang Q., Chen L., Wang J., Liu J. & Ding X. (2015) A genome scan for selection signatures in pigs. PLoS One 10, e0116850.

17.  Pan D., Zhang S., Jiang J., Jiang L., Zhang Q. & Liu J. (2013) Genome-wide detection of selective signature in Chinese Holstein. PLoS One 8, e60440.

18.  Wang H., Jiang L., Liu X., Yang J., Wei J., Xu J., Zhang Q. & Liu J.F. (2013) A post-GWAS replication study confirming the PTK2 gene associated with milk production traits in Chinese Holstein. PLoS One 8, e83625.

19.  Wang H., Jiang L., Wang W., Zhang S., Yin Z., Zhang Q. & Liu J.F. (2014) Associations between variants of the HAL gene and milk production traits in Chinese Holstein cows. Bmc Genetics 15, 125.

20.  Wang H., Wang J., Sun S., Wang Y., Guo J., Ning C., Yang K. & Liu J.F. (2015) Identification of reference microRNAs for quantitative expression analysis in porcine peripheral blood mononuclear cells treated with polyinosinic-polycytidylic acid. International Journal of Immunogenetics 42, 217-25.

21.  Wang J., Jiang J., Fu W., Jiang L., Ding X., Liu J.F. & Zhang Q. (2012) A genome-wide detection of copy number variations using SNP genotyping arrays in swine. BMC Genomics 13, 273.

22.  Wang J., Jiang J., Wang H., Kang H., Zhang Q. & Liu J.F. (2014) Enhancing genome-wide copy number variation identification by high density array CGH using diverse resources of pig breeds. PLoS One 9, e87571.

23.  Wang J., Jiang J., Wang H., Kang H., Zhang Q. & Liu J.F. (2015) Improved Detection and Characterization of Copy Number Variations Among Diverse Pig Breeds by Array CGH. G3  5, 1253-61.

24.  Wang J., Wang H., Jiang J., Kang H., Feng X., Zhang Q. & Liu J.F. (2013) Identification of genome-wide copy number variations among diverse pig breeds using SNP genotyping arrays. PLoS One 8, e68683.

25.  Wang J.Y., Luo Y.R., Fu W.X., Lu X., Zhou J.P., Ding X.D., Liu J.F. & Zhang Q. (2013) Genome-wide association studies for hematological traits in swine. Anim Genet 44, 34-43.

26.  Zhou C., Liu Z., Liu Y., Fu W., Ding X., Liu J., Yu Y. & Zhang Q. (2013) Gene silencing of porcine MUC13 and ITGB5: candidate genes towards Escherichia coli F4ac adhesion. PLoS One 8, e70303.

软件著作（第一排名）：

1.  贝叶斯A+基因组选择计算软件V1.0 (2014SRBJ0546)

2.  多性状贝叶斯Cπ基因组选择计算软件V1.0 (2014SRBJ0006)

3.  基于贝叶斯前相关模型的多性状基因组选择计算软件 (V1.02014SRBJ0480)

4.  贝叶斯Lasso基因组选择计算软件V1.0 (2013SRBJ0778)

5.  贝叶斯Cπ+基因组选择计算软件V1.0 (2013SRBJ0007)

6.  多性状贝叶斯A基因组选择计算软件V1.0 (2013SRBJ0824)

7.  贝叶斯B+基因组选择计算软件V1.0 (2013SRBJ0547)

8.  肉牛杂交遗传评估系统V1.0 (2010SRBJ5812)

9.  牛基因组单核苷酸多态性单机注释系统V1.0 (2011SRBJ2797)         

10.  牛基因组单核苷酸多态性在线注释系统V1.0 (2011SRBJ2798)

1. 2022年5月：猪全基因组50K芯片及应用（ZL2017800029815）

2. 2021年3月：一种母猪综合繁殖力的评价方法及其在猪育种中的应用（ZL2018112237618）

3. 2020年12月：一种与猪乳头内陷相关的SNP标记及其应用（ZL2019104860512）

4. 2019年12月：一种估计基因组育种值的方法及装置（ZL2017106517532）

2018年5月：一种与猪产仔数相关的CNV标记及其应用（ZL2015101911798）